Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
Read More
8
Zinc, cholesterol, and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
We delved into the intriguing relationship between trace minerals, specifically zinc, and high cholesterol levels related to coronary artery disease (CAD). Our study focused on middle-aged and older adults living in Shika town, Japan, and involved 895 residents, carefully excluding those with a genetic predisposition to high cholesterol.
By analyzing their dietary habits through a questionnaire, we found notable interactions between dyslipidaemia, or high cholesterol, and zinc intake. Our detailed examination revealed that a lower intake of zinc, alongside other trace minerals like copper and manganese, correlated with a higher risk of CAD in individuals with dyslipidaemia.
What we learned was striking: zinc, copper, and manganese emerged as significant factors linked to CAD, especially for those struggling with dyslipidaemia. The odds ratios suggested that sufficient zinc intake might play a protective role against CAD in these individuals. These findings illuminate the potential importance of trace minerals in maintaining heart health, particularly for those facing challenges with cholesterol levels. However, further research is essential to confirm these early observations and better understand the nature of these relationships.
Read More
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
Read More
Most Useful Reviews
9
Improves cardiovascular function
10 people found this helpful
Zinc has numerous benefits for the body, including enhancing immunity, fighting against high cholesterol, and promoting cardiovascular health. It also aids brain function, skin clarity, and enhances hair and nail strength. I find Zinc Balance capsules convenient since they contain both zinc and copper, which eliminates the need to purchase copper separately.
Read More
6
Supports cholesterol health
99 people found this helpful
Zinc is an essential trace element, but it can reduce copper levels in the body. The addition of copper is beneficial, as I previously took them separately. Combining zinc intake with quercetin or high-quality green tea is advisable. Also, consider pumpkin seed oil, which is rich in zinc. It’s a tasty addition to your diet. Wishing you good health!
Read More
7.5
Boosts immune response
80 people found this helpful
This product is of excellent quality and significantly strengthens the immune system, helping to tackle ailments more effectively. I highly recommend it!
Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
Read More
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
Read More
8
Zinc, cholesterol, and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
We delved into the intriguing relationship between trace minerals, specifically zinc, and high cholesterol levels related to coronary artery disease (CAD). Our study focused on middle-aged and older adults living in Shika town, Japan, and involved 895 residents, carefully excluding those with a genetic predisposition to high cholesterol.
By analyzing their dietary habits through a questionnaire, we found notable interactions between dyslipidaemia, or high cholesterol, and zinc intake. Our detailed examination revealed that a lower intake of zinc, alongside other trace minerals like copper and manganese, correlated with a higher risk of CAD in individuals with dyslipidaemia.
What we learned was striking: zinc, copper, and manganese emerged as significant factors linked to CAD, especially for those struggling with dyslipidaemia. The odds ratios suggested that sufficient zinc intake might play a protective role against CAD in these individuals. These findings illuminate the potential importance of trace minerals in maintaining heart health, particularly for those facing challenges with cholesterol levels. However, further research is essential to confirm these early observations and better understand the nature of these relationships.
Read More
8
Study on zinc and cholesterol outcomes
Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
We conducted a randomized clinical trial involving 75 patients with type 2 diabetes to explore the effects of a nutraceutical combination containing myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc on cholesterol levels.
While the overall results showed no significant improvement in glucose levels among the groups, we did observe reductions in total cholesterol and LDL levels in the supplement group after three months. Interestingly, a subgroup that did not change their diabetes medication displayed even greater improvements in cholesterol levels—suggesting potential benefits from the supplement combination.
However, it's important to note that the study did not assess the specific impact of zinc alone on cholesterol. Therefore, while we found promising results for the combination used, we cannot definitively attribute any cholesterol-lowering effects directly to zinc in isolation.
Read More
7
Zinc's role in cholesterol management
The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats.
In our study, we explored how zinc supplementation might influence cholesterol levels in a controlled experiment with male Wistar rats. We divided the 48 rats into three diet groups: those on a high-fat diet, a caloric restriction diet, and a normal diet. The high-fat diet group was further split into four categories, where some received zinc, selenium, or a combination of both, while one group served as the control.
After eight weeks of monitoring, we conducted biochemical tests to assess key factors such as triglyceride levels, cholesterol, and blood sugar. Although zinc has potential benefits, our findings suggest that its supplementation did not significantly lower cholesterol levels when compared to the control group on a high-fat diet. Despite the lack of notable changes, this research indicates that more studies are needed to understand zinc's role in managing high cholesterol, especially when combined with other supplements.
We came to realize that while zinc and selenium have their merits, they might not directly target high cholesterol levels effectively within this specific model. The complexity of obesity-related conditions requires a deeper investigation into individual nutrient effects and their interactions.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Improves cardiovascular function
10 people found this helpful
Zinc has numerous benefits for the body, including enhancing immunity, fighting against high cholesterol, and promoting cardiovascular health. It also aids brain function, skin clarity, and enhances hair and nail strength. I find Zinc Balance capsules convenient since they contain both zinc and copper, which eliminates the need to purchase copper separately.
Read More
6
Supports cholesterol health
99 people found this helpful
Zinc is an essential trace element, but it can reduce copper levels in the body. The addition of copper is beneficial, as I previously took them separately. Combining zinc intake with quercetin or high-quality green tea is advisable. Also, consider pumpkin seed oil, which is rich in zinc. It’s a tasty addition to your diet. Wishing you good health!
Read More
7.5
Boosts immune response
80 people found this helpful
This product is of excellent quality and significantly strengthens the immune system, helping to tackle ailments more effectively. I highly recommend it!
Read More
Frequently Asked Questions
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc plays a crucial role in various bodily functions, including immune system support and wound healing, but its effect on cholesterol levels is not well-established. Some studies suggest that zinc may have a modest impact on lipid profiles, including potentially lowering levels of total cholesterol and triglycerides. However, these findings are not conclusive enough to recommend zinc supplementation as a primary treatment for high cholesterol.
If you're considering zinc supplements for cholesterol management, it's essential to consult with a healthcare professional first. They can provide personalized guidance based on your individual health needs and suggest more established lifestyle changes, such as a balanced diet and regular exercise, which are proven strategies for managing cholesterol levels effectively. Remember that while supplements can support health in specific areas, they should not replace conventional treatment methods prescribed by your doctor.
Zinc supplementation has shown potential in influencing cholesterol levels, particularly in individuals with type 2 diabetes. A study involving 80 patients discovered that those who received 50 mg of zinc daily experienced significant reductions in low-density lipoprotein (LDL) cholesterol and triglycerides over a year, suggesting a beneficial impact for cholesterol management [1]. Moreover, a meta-analysis of 19 clinical trials indicated that zinc could lead to reductions in total cholesterol and LDL levels, alongside an increase in high-density lipoprotein (HDL) cholesterol, the "good" cholesterol [4].
However, while these findings are promising, zinc's effects on cholesterol are not yet fully conclusive. Some studies highlighted that zinc did not lead to significant changes in HDL levels or overall body weight, and while it might support cholesterol management, its role needs further investigation [3]. Additionally, in cases where zinc was part of a nutraceutical combination, the outcomes were more favorable, though the specific contribution of zinc alone remains uncertain [5]. Therefore, while zinc supplementation might aid those managing high cholesterol, additional research is necessary to firmly establish its efficacy.
Based on user reviews, many individuals have reported notable improvements in various health symptoms after using Zinc Balance capsules. Users highlighted enhanced immunity, with one reviewer stating that the product significantly strengthens the immune system and helps tackle ailments more effectively Read Review. Others mentioned benefits related to cardiovascular health and brain function, underscoring the multifaceted advantages of incorporating zinc and copper into their routine Read Review.
Moreover, some users noted the convenience of this product, as it combines zinc with copper, which is crucial since zinc can reduce copper levels in the body. This merger eliminates the hassle of purchasing copper separately, making it a more efficient choice for those looking to maintain balanced nutrition and health Read Review. However, it's important to remember that individual results may vary, and what works for one person may not work for another.
According to user reviews, individuals managing high cholesterol reported favorable results when combining Zinc Balance capsules with other supplements. A reviewer specifically mentioned that incorporating quercetin or high-quality green tea alongside zinc can enhance overall health outcomes, particularly in the context of cardiovascular health and cholesterol management Read Review. Additionally, the product itself is appreciated for its dual inclusion of zinc and copper, which is said to support heart health and may contribute to fighting high cholesterol Read Review.
Moreover, users noted that supplementing with pumpkin seed oil, which is rich in zinc, can be a tasty and nutritious addition to their diet for managing cholesterol levels. This versatility underscores the importance of a comprehensive approach to supplementation, particularly for those looking to optimize their health Read Review. Overall, combining Zinc Balance with other supportive supplements seems to be a popular strategy among users in their journey toward handling high cholesterol.
Research indicates that zinc supplementation can positively impact cholesterol levels, particularly for those with type 2 diabetes. In a study involving 80 patients, a daily dose of 50 mg of zinc led to significant reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, with LDL dropping an average of 25.06 mg/dL [1]. Additionally, another review of 19 randomized controlled trials found that zinc supplementation was associated with decreases in triglycerides by 17.41 mg/dL and total cholesterol by 19.60 mg/dL, supporting the idea that a 50 mg daily dose may be beneficial [4].
However, it’s crucial to note that while zinc has shown promise for lowering some types of "bad" cholesterol, results on its effects on "good" cholesterol (HDL) and overall body weight remain mixed, with some studies showing no significant changes [1]. More research is needed to fully understand zinc's role in cholesterol management, particularly regarding its efficacy compared to other dietary interventions and its interactions with other nutrients [3]. As such, anyone considering zinc for cholesterol management should consult with a healthcare professional to assess individual needs and potential benefits.
7.5
Boosts immune response
80 people found this helpful
This product is of excellent quality and significantly strengthens the immune system, helping to tackle ailments more effectively. I highly recommend it!
9
Improves cardiovascular function
10 people found this helpful
Zinc has numerous benefits for the body, including enhancing immunity, fighting against high cholesterol, and promoting cardiovascular health. It also aids brain function, skin clarity, and enhances hair and nail strength. I find Zinc Balance capsules convenient since they contain both zinc and copper, which eliminates the need to purchase copper separately.
6
Supports cholesterol health
99 people found this helpful
Zinc is an essential trace element, but it can reduce copper levels in the body. The addition of copper is beneficial, as I previously took them separately. Combining zinc intake with quercetin or high-quality green tea is advisable. Also, consider pumpkin seed oil, which is rich in zinc. It’s a tasty addition to your diet. Wishing you good health!
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
9
Zinc improves cholesterol levels
Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
7
Zinc's role in cholesterol management
The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats.
In our study, we explored how zinc supplementation might influence cholesterol levels in a controlled experiment with male Wistar rats. We divided the 48 rats into three diet groups: those on a high-fat diet, a caloric restriction diet, and a normal diet. The high-fat diet group was further split into four categories, where some received zinc, selenium, or a combination of both, while one group served as the control.
After eight weeks of monitoring, we conducted biochemical tests to assess key factors such as triglyceride levels, cholesterol, and blood sugar. Although zinc has potential benefits, our findings suggest that its supplementation did not significantly lower cholesterol levels when compared to the control group on a high-fat diet. Despite the lack of notable changes, this research indicates that more studies are needed to understand zinc's role in managing high cholesterol, especially when combined with other supplements.
We came to realize that while zinc and selenium have their merits, they might not directly target high cholesterol levels effectively within this specific model. The complexity of obesity-related conditions requires a deeper investigation into individual nutrient effects and their interactions.
8
Study on zinc and cholesterol outcomes
Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
We conducted a randomized clinical trial involving 75 patients with type 2 diabetes to explore the effects of a nutraceutical combination containing myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc on cholesterol levels.
While the overall results showed no significant improvement in glucose levels among the groups, we did observe reductions in total cholesterol and LDL levels in the supplement group after three months. Interestingly, a subgroup that did not change their diabetes medication displayed even greater improvements in cholesterol levels—suggesting potential benefits from the supplement combination.
However, it's important to note that the study did not assess the specific impact of zinc alone on cholesterol. Therefore, while we found promising results for the combination used, we cannot definitively attribute any cholesterol-lowering effects directly to zinc in isolation.
References
Chhina GS, Chhabra A, Luthra SR, Khattar S, Singh P, et al. Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus. Cureus. 2024;16:e69180. 10.7759/cureus.69180
Kimura K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, et al. Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study. J Nutr Sci. 2024;13:e45. 10.1017/jns.2024.26
Hasani M, Monfared V, Aleebrahim-Dehkordi E, Jafari A, Agh F, et al. The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats. Curr Mol Med. 2024;24:1307. 10.2174/0115665240268180231113045836
Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. 10.1007/s12011-024-04059-x
Nani A, Bertuzzi F, Meneghini E, Mion E, Pintaudi B. Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. J Clin Med. 2023;12. 10.3390/jcm12247650